Preface

SECTION I Theories of Aging

1. Theories of Aging, H.J. Armbrecht, R.M. Coe

2. Biological and Evolutionary Perspectives on Aging, B. Charlesworth

3. Genetic Determinants of Aging, G.M. Martin

4. Free Radical Theory of Aging, J. Blumberg

5. Modification of Proteins During Aging, R. Levine, E. Stadtman

6. Somatic DNA Alterations and Aging, J. Vijg

7. Mitochondria and Aging, E.J. Brierly, D.M. Turnbull, O.F.W. James

8. Apoptosis, M. Deshmukh, E.M. Johnson

9. Gender and Longevity, J.E. Morley

10. Caloric Restriction in Aging: Studies in Rodents and Primates, J. Wanagat, R. Weindruch

SECTION II Animal Models of Aging

11. Postponed Aging in Fruit Flies, M.R. Rose

12. Genetic Influences on Lifespan in Nematodes, T.E. Johnson

13. Evolutionary Biology: Crustacea as a Model of Aging, J.L. Dudycha

14. SAM Mice as Models of Aging, T. Takeda

SECTION III Regulation of Cell Growth: Changes in Senescence

15. Overview of Cellular Senescence, V.J. Cristofalo

16. Telomeres and Aging: The Long and the Short of It, L. Hayflick

17. Molecular Basis for the Defective Regulation of the Cell in Aging and Cancer, T.V. Zenser, V.M. Lakshmi, B.B. Davis

18. Aging in the Endothelium, Y. Dohi, M. Kojima, K. Miyagawa, K. Sato

SECTION IV Alterations in Homeostasis with Age: The Role of Hormones

19. Growth Hormone, J.E. Morley

20. Thyroid Changes with Aging, C.C. Case, A. Mooradian

21. Catecholamines and Aging, M. Supiano, R.V. Hogikyan

22. Male Sexual Function and Aging, J.E. Morley

23. Aging and the Female Hypothalamus, P.M. Wise

24. Cortisol, Stress, and Aging, J.E. Morley

25. Melatonin and Aging, R.J. Reiter

26. DHEA, Pregnenolone, and Aging, R. Sih

27. Thermoregulation, N. Wongsurawat

SECTION V Nutrition

28. Pathogenesis of Anorexia in Aging, J.E. Morley

29. Vitamins and Aging, L. Johnson

30. Neurohormonal Regulation of Water Homeostasis, K. Jayaraj, J.E. Morley

31. Age-Related Carbohydrate Intolerance, J.E. Thurman, A. Mooradian

32. Altered Calcium Homeostasis and Age-Related Bone Loss, H.J. Armbrecht

33. Aging Bone, S. Bakshi, J.E. Morley

SECTION VI The Aging Brain

34. The Genetics of Alzheimer's Disease, W.J. Ray, A.M. Goate

35. Beta Amyloid, Cell Toxicity, and Alzheimer's Disease, J.N. Octave

36. Complement Regulators in Alzheimer's Disease, V.B. Kumar

37. Cell Calcium, Memory, and Aging, H.J. Armbrecht

38. Prion Diseases Including Bovine Spongiform Encephalopathy (Mad Cow Disease), S.G. Chen, P. Parchi, P. Gambetti

39. Age-Related Changes in Learning, Memory, and Memory Processing, J. Flood, J.E. Morley

40. The SAM Mouse: A True Model of Alzheimer's Disease?, J.E. Morley, J. Flood, V.J. Kumar

41. The Senescent Blood-Brain Barrier, W.A. Banks

SECTION VII The Aging Immune System

42. Immunosenescence: An Overview, J.E. Morley

43. Aging-Related Changes in Cytokine Expression by T Cells, D.N. Ernst, M.V. Hobbs

44. Age-Related Changes in Cellular Immune Responses, J.E. McElhaney

45. The Thymus and Aging, N. Fabris

46. Effect of Vitamin E on Infection and Immunity, M.G. Hayek, S. Meydani

47. Psychoneuroimmunology, G. Solomon

SECTION VIII Other Organ Systems

48. Muscle Protein and Aging, K. Yarasheski, J.J. Zachwieja

49. Hematopoiesis in the Elderly, G.S. Chatta, M. Kohli, D.A. Lipschitz

50. Aging of the Gastroinetestinal System, R.M. Shishodia, J.E. Morley

51. Gastrointestinal Hormones, A.S. Nicolas, B. Vellas, J.E. Morley

52. Aging Urinary Bladder, M. Naeem, L. Naeem, J.E. Morley

53. Molecular and Physiological Changes in the Heart, S. Herrmann, D.D. Miller

54. Drug Metabolism in Older Persons, U. Javaid, J.E. Morley

55. The Aging Fat Cell, G. Wittert, J.E. Morley